Impact of a Multi-Center Collaborative on Antibiotic Duration for Acute Respiratory Infections in Pediatric Urgent Care.

Authors

Amanda Nedved, Brian Lee, Luis E Sainz, Matthew P Kronman, Adam L Hersh, Victoria Parente, Rana F Hamdy, Rana E El Feghaly, Reducing Differences in Urgent Care Encounters for Antibiotic Choice (ReDUCE: Antibiotic Choice) Quality Improvement Collaborative

Published in

Journal of the Pediatric Infectious Diseases Society. Oct 06, 2026. Epub Oct 06, 2026.

Abstract

Updated guidance for common acute respiratory infections (ARIs) recommends shorter antibiotic durations. While stewardship efforts often focus on appropriate antibiotic selection, it remains unclear whether initiatives targeting first-line choice also influence duration.
We conducted a secondary analysis of a national quality improvement collaborative including 92 pediatric urgent care sites across 9 organizations in 22 states and Washington, D.C. (April 2022-September 2024). The collaborative emphasized equitable first-line antibiotic selection; duration was not an explicit target. We included encounters for patients aged 6 months-18 years with ARI International Classification of Diseases-10 (ICD-10) diagnoses resulting in an antibiotic prescription and excluded azithromycin. October 2023-April 2024 was defined as the intervention period during active Plan-Do-Study-Act cycles. The primary outcome was short-course prescribing (≤7 days). Multivariable, multilevel logistic regression models estimated odds of ≤7-day duration across time periods (pre-collaborative, intervention, post-collaborative) and sociodemographic groups.
Among 257 879 encounters, acute otitis media was most common (160 292; 62.2%). We saw an increase in ≤7-day duration prescribing from 33.4% pre-collaborative to 35.9% during the intervention and 37.8% post-collaborative. This increase was most notable for sinusitis (11.2% pre-collaborative to 33.9% post-collaborative). Compared with the pre-collaborative period, odds of ≤7-day duration were higher during intervention (aOR 1.22, 95% CI 1.18, 1.25, p < 0.001) and post-collaborative periods (aOR 1.31, 95% CI 1.27, 1.35, p < 0.001). Differences in duration were observed by race, language, and payor type.
During a collaborative focused on equitable first-line antibiotic selection, short-course prescribing increased, suggesting potential spillover to duration alongside broader secular trends. Persistent sociodemographic differences highlight the need to explicitly incorporate equity into outpatient stewardship efforts beyond antibiotic choice.

PMID:
42837306
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.

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