Recent Progress in Understanding the Mechanism of Formate Dehydrogenases.

Authors

Russ Hille, Dimitri Niks

Published in

Chembiochem : a European journal of chemical biology. Volume 27. Issue 19. Pages e70555. Oct 14, 2026.

Abstract

Recent work concerning the reaction mechanism of the molybdenum-containing formate dehydrogenases is discussed, focusing on two alternate mechanisms of action for the enzyme involving either formation of CO₂ or bicarbonate as the immediate product of the reaction. On the basis of the pH dependence of the rate of reduction of enzyme by formate and the results of a recent GC/MS study undertaken under single-turnover conditions indicating that no ¹⁸O from solvent H₂ ¹⁸O is incorporated into product CO₂, it is concluded that bicarbonate cannot be formed in the course of the reaction, and that cysteine, once dissociated from the molybdenum, cannot be functioning as a base in the course of the reaction.

PMID:
42837427
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.

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