ASTROREPOMICS: A curated transcriptomic database for reproductive biology in space.

Authors

Chun-Fan Lung, Kun-I Lin, Yi-Chiung Hsu

Published in

iScience. Volume 29. Issue 4. Pages 115309. Apr 17, 2026. Epub Mar 10, 2026.

Abstract

Spaceflight imposes substantial physiological stress on reproductive systems, yet relevant transcriptomic data remain fragmented across repositories. To address this need, we developed ASTROREPOMICS, a web-based platform that integrates 17 rigorously normalized and batch-corrected transcriptomic datasets spanning multiple species and reproductive tissues. The platform supports reproducible cross-study and cross-species analyses through standardized metadata and an intuitive user interface. We highlight its utility through two example analyses: (1) irradiated mouse sperm exhibited suppression of RNA splicing and protein-processing pathways alongside activation of interferon- and GPCR-associated programs; and (2) a multi-species intersected-DEG assessment between irradiated rat mammary tissue and microgravity-exposed zebrafish embryos uncovered conserved signatures involving RNA metabolism, cytokine signaling, and angiogenesis. By consolidating dispersed datasets and offering tailored analytical capabilities, ASTROREPOMICS provides a centralized resource for hypothesis generation and strengthens the research infrastructure needed to advance reproductive health studies in space, supporting long-term efforts to safeguard fertility during deep-space exploration.

PMID:
41940322
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.

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