The oxysterolome iterative metabolism expands sterol signaling.

Authors

Silia Ayadi, Julio Buñay, Sandrine Silvente-Poirot, Philippe de Médina, Marc Poirot

Published in

Trends in endocrinology and metabolism: TEM. Sep 22, 2026. Epub Sep 22, 2026.

Abstract

Oxysterols are generally viewed as individual signaling molecules regulating lipid homeostasis, immunity, development, and disease. However, many primary oxysterols are metabolic hubs that undergo iterative enzymatic transformations, generating secondary and higher-order metabolites with distinct biological activities. We propose the oxysterolome to describe this interconnected network of oxygenated sterols and their metabolic descendants. Through receptor diversification, functional divergence, and the emergence of novel biological activities, iterative metabolism expands the informational and functional diversity of cholesterol-derived signaling. Deciphering the oxysterolome will require moving from the study of individual metabolites toward reconstruction of interconnected metabolic networks, providing new perspectives for understanding endocrine regulation, aging, immunity, and disease.

PMID:
42838870
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.

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