Authors
Erik Boberg, Giulia Merigo, Gabriel Riva, Mattias Ringh, Giuseppe Ristagno, Martin Jonsson, Cecilia Nordius, Aurora Magliocca, Markus B Skrifvars, Fredrik Byrsell, Fredrik Jonsson, Andreas Claesson, Leif Svensson, Per Nordberg, Annette Nord, Jacob Hollenberg
Published in
American heart journal. Pages 107623. Oct 06, 2026. Epub Oct 06, 2026.
Abstract
Bystander cardiopulmonary resuscitation (CPR) before emergency medical services arrival is associated with improved survival after out-of-hospital cardiac arrest (OHCA). Compression-only CPR (CO-CPR) is simpler to teach and perform, eliminates interruptions in chest compressions for rescue breaths, and has been associated with higher bystander CPR rates. For adults with OHCA of presumed medical etiology, clinical equipoise remains regarding the optimal CPR strategy for previously trained bystanders.
Bystander CO-CPR is non-inferior to standard CPR (S-CPR) for 30-day survival in dispatch-assisted out-of-hospital cardiac arrest DESIGN: TANGO2 is an international, multicenter, randomized, open-label, non-inferior trial. Dispatchers randomize eligible cases 1:1 to CO-CPR or S-CPR via an integrated decision-support system. Protocol adherence is evaluated via systematic dispatch audio review. Per-protocol (PP) analysis is prespecified as the primary analysis, supported by modified intention-to-treat (mITT) analysis. Non-inferiority is defined as an absolute risk difference above -1.0 percentage points.
All Emergency Medical Dispatch Centers in Sweden and selected sites in Italy.
3,260 per-protocol EMS-treated OHCA patients ENROLLMENT DATES: Start date: 2017. Estimated completion date: December 2027.
Enrolling.
ClinicalTrials.gov Identifier: NCT03981107, https://clinicaltrials.gov/study/NCT03981107.
PMID:
42838476
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.
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