Authors
Jason L Hornick, Judith V M G Bovee, Cristina R Antonescu, Daniel Baumhoer, David Creytens, Angelo P Dei Tos, Cyril Fisher, Andrew L Folpe, Meera Hameed, Alexander J Lazar, Markku Miettinen, G Petur Nielsen, Yoshinao Oda, Nasir Ud Din, Jian Wang, Akihiko Yoshida, Jean-Yves Blay, Johan L Bloem, Alessandro Gronchi, Fredrik Mertens, Christina Messiou, Jennelle C Hodge, Joseph D Khoury, Andrew Field, Bharat Rekhi, Harshima Wijesinghe, Pavitratha Puspanathan, Fikret Dirilenoglu, Christine Giesen, Blanca I Indave Ruiz, Dilani Lokuhetty, WCT Standing Editorial Board
Published in
The American journal of surgical pathology. Oct 07, 2026. Epub Oct 07, 2026.
Abstract
The 6th edition of the World Health Organization Classification of Soft Tissue and Bone Tumors (STB6) integrates the latest scientific and molecular discoveries with decades of pathological expertise to establish a globally accepted common language for diagnosis and clinical behavior. In this volume, the "essential" and "desirable" diagnostic criteria have been refined, considering different resource settings, ensuring accuracy while maintaining flexibility. A tumor type (entity) is a tumor in which multiple parameters (eg, clinical, histopathological, and/or genetic features) differ from those of other tumor types. In total, 19 new entities met these criteria and were added. A subtype is different in at least one dimension from the main tumor type (clinical, histopathological, or genetic), preferably resulting in a different treatment or outcome. A morphological pattern (no longer "variant") is important for pathologists to be aware of to facilitate recognition but is not associated with different clinical behavior. The classification was drafted by 203 editors and authors from 27 countries, representing genetics, medical oncology, surgical oncology, orthopedic surgery, and radiology, in addition to pathology. STB6 includes soft tissue tumors (n=116), bone tumors (n=46), vascular tumors of soft tissue and bone (n=18), undifferentiated spindle and round cell sarcomas (n=4), hematopoietic and dendritic cell neoplasms (n=6), and genetic syndromes (n=6). In total, 62 sarcomas are included. A consensus was reached among the expert editorial board. In this review, we highlight changes in tumor classification in STB6, including recently described tumor types, novel diagnostic markers, recent discoveries in molecular genetics, and improvements in prognostication.
PMID:
42839882
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.
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