Evolutionarily conserved selective autophagy pathways.

Authors

András Jipa, Virág Vincze, Daniela Evdokimova, Dániel Dénes, Lilla Beatrix Péter, Zsombor Esküdt, Bence Csaba Béres, Gábor Juhász

Published in

Autophagy. Pages 1-26. Oct 06, 2026. Epub Oct 06, 2026.

Abstract

Selective autophagy is a regulated process that ensures the specific recognition and lysosomal degradation of defined intracellular substrates, including damaged organelles, protein aggregates, and invading pathogens. Despite intense research interest, several mechanistic aspects of selective autophagy remain incompletely understood. Comparative analysis across different models offers a valuable framework for identifying evolutionarily conserved molecular components and regulatory principles. In this review, we provide a detailed overview of seven major evolutionarily conserved selective autophagy pathways: mitophagy, xenophagy, pexophagy, lysophagy, ER-phagy, Golgiphagy, and ribophagy, building on data from four widely used model organisms (mammals, Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae). We focus on the core molecular machinery including the modes of cargo recognition via already characterized and predicted selective receptors, and orchestration of cargo capture into forming autophagosomes.

PMID:
42839605
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.