γ-aminobutyric acid type A receptors modulate neurosteroid binding to the voltage-dependent anion channel.

Authors

Natalia Akentieva

Published in

Acta chimica Slovenica. Volume 73. Issue 3. Pages 604-614. Jul 20, 2026. Epub Jul 20, 2026.

Abstract

Neurosteroids modulate the function of γ-aminobutyric acid type A (GABAA) receptors in the brain. We showed that GABAA receptors modulate neurosteroid interactions with VDAC. GABA enhanced [3H]6-AziP labeling of VDAC in a concentration-dependent manner. This effect of GABA was prevented by the GABAA receptor antagonists gabazine and picrotoxin. Studies with brain tissue from mice deficient for VDAC showed that GABA enhanced [3H]6-AziP labeling of VDAC2 and VDAC1. GABA enhanced photolabeling of VDAC in HEK cells expressing γ2L-subunit, suggesting that the γ2L-subunit is required for the interaction of GABAA receptors with VDAC. VDAC1 and VDAC2 both co-immunoprecipitated with GABAA receptors in rat brain membranes. Collectively, the data provide evidence for a direct signaling pathway between the synaptic plasma membrane GABAA receptor and VDAC, a mitochondrial outer membrane protein.

PMID:
42839564
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.

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