A Rare Case of Acquired Haemophilia A Following Sigmoid Adenocarcinoma: Case Report and Literature Review.

Authors

Benjamin Reardon, Harini Haran, Jennifer Curnow

Published in

Asia-Pacific journal of clinical oncology. Oct 06, 2026. Epub Oct 06, 2026.

Abstract

Acquired haemophilia A (AHA) is a rare autoimmune bleeding disorder resulting from the development of inhibitory autoantibodies against factor VIII (FVIII). Malignancy is a recognised association, although colorectal cancer remains an uncommon underlying cause. We report a 68-year-old woman with sigmoid adenocarcinoma who developed severe postoperative haemoperitoneum associated with progressive activated partial thromboplastin time prolongation, an initial FVIII activity of 52 IU/dL that subsequently declined to 2 IU/dL, and development of an FVIII inhibitor measuring 9.7 BU. The case highlights diagnostic challenges associated with AHA, particularly the risk of delayed diagnosis and the complexities of balancing immunosuppressive intensity alongside haemostatic therapy. We then present a review of current literature to guide management for this rare condition and emerging therapies.

PMID:
42839549
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.

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