Incremental effect and risk association of obstructive coronary artery disease on microvascular myocardial ischemia in T2DM patients evaluated via CT myocardial perfusion.

Authors

Wangshu Zhu, Yijia Xiong, Yidong Jin, Runjianya Ling, Geng Gu, Zhihan Xu, Jian Ma, Yue-Hua Li

Published in

Frontiers in cardiovascular medicine. Volume 13. Pages 1897324. Epub Sep 22, 2026.

Abstract

Microvascular myocardial ischemia (MMI) in patients with T2DM may be influenced by the presence of concomitant obstructive coronary artery disease (OCAD). Our investigation focused on assessing the impact of OCAD on MMI and delineating the prognostic relevance of MMI.
This study included four groups: (1) control group without OCAD (n = 125), (2) control group with OCAD (n = 99); (3) T2DM patients without OCAD (n = 100); (4) T2DM patients with OCAD (n = 93). All patients received dynamic computed tomography myocardial perfusion imaging (CT-MPI) as well as coronary computed tomography angiography (CCTA). Univariate and multivariate linear regression analyses were performed to identify independent determinants of clinical characteristics and perfusion metrics related to MMI. Major adverse cardiovascular events (MACEs) were documented, and the prognostic significance of CT-MPI compared with clinical variables was assessed.
The myocardial blood flow (MBF) stepwise reduced from the control (OCAD-), T2DM (OCAD-), control (OCAD+) to T2DM (OCAD+) group (p < 0.05). Independent associations were observed between global MBF and OCAD or T2DM (OCAD: p < 0.05, R² = 0.154; T2DM: β = -11.96, p < 0.001, R² = 0.101). A significant association was observed between OCAD and global MBF in the circumstance of T2DM (R² = 0.176). An independent association was observed between the global MBF and MACEs (p < 0.05).
Dynamic CT-MPI combined with CCTA demonstrated that the presence of OCAD in T2DM patients is associated with a greater occurrence of MMI. MBF emerged as a robust predictor of cardiovascular outcomes in this population.

PMID:
42839927
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.