Analysis and Interpretation of a Hierarchical Outcome in a Small Pilot Randomized Trial: An Example in the CORTAHF Trial.

Authors

Jan Biegus, Christopher Edwards, Gary Koch, Gad Cotter, Yonathan Freund, Adriaan A Voors, Koji Takagi, Piotr Ponikowski, Gerasimos Filippatos, Ovidiu Chioncel, Matteo Pagnesi, Marco Metra, Douglas L Mann, Beth Davison

Published in

European heart journal. Cardiovascular pharmacotherapy. Oct 07, 2026. Epub Oct 07, 2026.

Abstract

Hierarchical composite endpoints (HCE) analyzed using generalized pairwise comparisons (GPC) have been increasingly adopted in cardiovascular trials. Stratified, but not covariate-adjusted, win statistics have been frequently presented. We apply methods to a post hoc HCE for the randomized 100-patient CORTAHF pilot trial of short-term corticosteroid therapy in acute heart failure (AHF).
The HCE comprised 90-day death, 90-day HF readmission, 30-day worsening HF, and 30-day change in EQ-5D visual analogue scale (EQ-VAS) score from baseline. Win statistics and patient ranks from worst to best outcome were derived from GPC. These ranks were used to produce site-stratified and baseline EQ-VAS-adjusted win odds.Analysis of individual components suggested beneficial prednisone effects on 90-day HF readmission and 30-day WHF adverse events, with little effect on 30-day change in EQ-VAS. The win ratio and win odds were 1.82 and 1.71, respectively (both p<0.05), with 10% ties remaining after most comparisons were resolved at the last tier. HF readmission contributed most to the overall win difference of 26.1%. Stratification and baseline covariate adjustment using patients' ranks were feasible, but in this example did not substantially alter the estimated win odds.
Patients' ranks can be derived from GPC and used to estimate stratified and covariate-adjusted win statistics as well as to visualize the treatment effect. Use of a well-constructed HCE in a small pilot trial should be considered; a positive signal may support further examination of the treatment. A full analysis can aid in interpretation.

PMID:
42839766
Bibliographic data and abstract were imported from PubMed on 07 Oct 2026.

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