Authors
Tamba Marc Sandouno, Mathilde Vermersch, Jeremy Passos, Laté Mawuli Lawson-Ananissoh, Thomas Mercier, Esse Sylvestre Tsogli
Published in
La Revue de medecine interne. Oct 07, 2026. Epub Oct 07, 2026.
Abstract
AL amyloidosis is a rare disorder characterized by the extracellular deposition of immunoglobulin light chain fibrils produced by a clonal plasma cell population. Hepatic involvement as the initial manifestation is rare, and forms associated with jaundice and cholestasis carry a poor prognosis.
We report the case of a 53-year-old man from Togo presenting with massive hepatomegaly, cholestatic jaundice, and weight loss. After a negative etiological workup, diffuse hepatic infiltration associated with a plasma cell dyscrasia raised suspicion of AL amyloidosis. Peripheral biopsies were negative. The diagnosis was confirmed by transjugular liver biopsy, showing κ light chain amyloid deposits associated with a monoclonal plasma cell proliferation. Despite anti-clonal therapy using the ANDROMEDA protocol, the clinical course was rapidly fatal.
This case highlights the critical importance of early diagnosis when facing unexplained cholestatic hepatomegaly.
PMID:
42844126
Bibliographic data and abstract were imported from PubMed on 08 Oct 2026.
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