On the nature of GABA_B receptors and their plasticity in the mammalian brain.

Authors

Sam A Booker

Published in

Trends in neurosciences. Sep 22, 2026. Epub Sep 22, 2026.

Abstract

Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter of the mammalian CNS, essential for circuit function and behaviour. In the brain, GABA activates GABA_A and GABA_B receptors to modulate circuit activity on behaviourally relevant timescales. GABA_B receptor signalling in pre- and postsynaptic domains of neurons is often overlooked, despite the strong inhibition it produces. Importantly, GABA_B receptors are diversely phosphorylated and interact with various auxiliary subunits to modify function. This review compares the evidence for the expression and modulation of GABA_B receptors, their effectors, and regulatory mechanisms between cell types, brain areas, and mammalian species, particularly focusing on the plasticity of these mechanisms and their relationship to neurological diseases such as epilepsy and dementia.

PMID:
42844061
Bibliographic data and abstract were imported from PubMed on 08 Oct 2026.

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