Two ergostane-type steroids from the endophytic fungus Phomopsis sp. ZM-1.

Authors

Jialiang Huang, Mengsha Wei, Peng Zhou, Xueying Deng, Yuyi Zheng, Qin Li, Mi Zhang, Yonghui Zhang, Hucheng Zhu

Published in

Fitoterapia. Pages 107512. Oct 07, 2026. Epub Oct 07, 2026.

Abstract

Two undescribed ergostane-type steroids, phomopsteroids A and B (1 and 2), along with six known analogues (3-8), were isolated from the endophytic fungus Phomopsis sp. ZM-1. Structurally, compounds 1 and 2 feature an unprecedented 6,7-seco tricyclic carbon framework. Their structures and absolute configurations were unambiguously elucidated using comprehensive spectroscopic analyses, including HRESIMS, NMR, and UV spectroscopy, supplemented by electronic circular dichroism (ECD). Compound 6 exhibited a notable cytotoxic effect against A549 human lung carcinoma cells, with an IC₅₀ value of 7.21 μM.

PMID:
42843733
Bibliographic data and abstract were imported from PubMed on 08 Oct 2026.

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