Authors
Tomoyuki Toge, Moyuri Inoue, Ying-Ying Chou, Anna Yoshimura, Sachiko Yamashita-Takeuchi, Kayoko N Kuroishi, Kaori K Gunjikake, Jun J Miyamoto, Takuma Matsubara, Osamu Kaminuma, Tatsuo Kawamoto, Shoichiro Kokabu
Published in
Experimental animals. Oct 07, 2026. Epub Oct 07, 2026.
Abstract
Dorsal skin is widely used in mouse wound-healing, dermatitis, and hair-cycle models, but is often treated as a uniform site, even though spatial heterogeneity of the hair cycle, such as regenerative hair waves along the body axis, has been reported. We investigated whether adhesive material (cyanoacrylate)-induced hair regeneration, a model we previously reported, shows a reproducible difference in the timing of hair regrowth by position within the dorsal skin. Adhesive material was applied to four regions along the cranial-to-caudal axis of the mouse dorsal skin. Hair regrowth appeared earlier at the cranial sites than at the caudal sites, and this difference persisted through late anagen and the anagen-to-catagen transition. Expression of Hox genes, including Hoxa9, Hoxb9, Hoxc9, Hoxa10, and Hoxc10, was higher at the caudal sites than at the cranial sites but did not correlate with the timing of hair regrowth. The adipogenic genes Pparg and Fabp4 were lower in caudal than in cranial skin. Early after adhesive material application, histological changes and the expression of inflammation- and tissue-repair-related genes also differed between the cranial and caudal skin. These findings indicate that, within this model, the timing of hair-regrowth onset differs reproducibly by cranial-to-caudal position, and that this position should be considered when designing and interpreting hair-regeneration experiments using this model.
PMID:
42844172
Bibliographic data and abstract were imported from PubMed on 08 Oct 2026.
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