Authors
Samaneh Sepahi, Habibeh Mashayekhi-Sardoo, Adel Ghorani Azam, Sina Gerayli, Prashant Kesharwani, Amirhossein Sahebkar
Published in
Molecular nutrition & food research. Volume 70. Issue 19. Pages e70623.
Abstract
Microplastic (MP; MPs) and nanoplastic (NP; NPs) pollution poses a growing threat to global health. Their small size and large surface area facilitate ingestion, accumulation, and interactions with biological systems, leading to toxicity through oxidative stress, inflammation, mitochondrial dysfunction, and cell death. These effects may occur directly or through the release of adsorbed pollutants and plastic additives. Resveratrol (3,5,4'-trihydroxy-trans-stilbene; RV), a natural polyphenol found in grapes, berries, and peanuts, has attracted interest as a potential protective agent because of its antioxidant and anti-inflammatory properties. Its proposed protective effects against MP/NP toxicity involve modulation of key cellular signaling pathways, particularly nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB). RV may activate Nrf2 by disrupting its interaction with Kelch-like ECH-associated protein 1 (Keap1), thereby enhancing antioxidant defenses, including superoxide dismutase, catalase, and glutathione peroxidase, and reducing reactive oxygen species-mediated damage to lipids, proteins, and DNA. Concurrently, RV may suppress NF-κB-mediated inflammatory responses. However, current evidence is limited to a small number of preclinical studies, with no human studies available. These mechanisms remain largely hypothetical and require validation using standardized MP/NP exposure models.
PMID:
42844955
Bibliographic data and abstract were imported from PubMed on 08 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 10
- Comments 0