An HOCl-responsive chemiluminescent probe for monitoring MPO-mediated HOCl generation for deep-tissue tracking and evaluation of inflammatory bowel disease.

Authors

Qiangchao Meng, Runsha Xiao, Jipeng Ding, Tianyu Zhu, Junpu Wang, Chengmin Li, Xueping Feng, Wenbin Zeng

Published in

Journal of materials chemistry. B. Oct 08, 2026. Epub Oct 08, 2026.

Abstract

By engineering the donor-acceptor scaffold of isoluminol, we developed 2TPA-IsoL, a novel chemiluminescent probe with red-shifted emission (600 nm), high HOCl selectivity, and prolonged kinetics. It enables deep-tissue imaging and therapeutic evaluation of inflammatory bowel disease, offering a generalizable strategy for long-wavelength chemiluminescent probe design.

PMID:
42845174
Bibliographic data and abstract were imported from PubMed on 08 Oct 2026.

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