Authors
Tomohito Okubo, Kouji Hara, Naoyuki Hatayama, Kota Takahashi, Eriko Yamazoe, Takaaki Ito, Takao Takeuchi, Yoko Koide, Mayumi Yamada, Munekazu Naito, Kohei Tahara
Published in
Advanced healthcare materials. Pages e71789. Oct 08, 2026. Epub Oct 08, 2026.
Abstract
Pulmonary air leak is the most common complication following lung surgery. Most materials used for pulmonary fistula closure rely on fibrin network-mediated adhesion. However, on the moist and dynamically deforming lung surface, these materials often fail to provide sufficient adhesion, and postoperative air leaks remain a major clinical concern. Since these materials are biologically derived, concerns regarding biosafety risks and high production costs persist. To address these limitations, this study develops a novel closure material that integrates biocompatibility, pressure resistance, tissue adhesion, and seal retention under wet conditions. The closure material is fabricated as a nanofiber sheet via electrospinning. Comparative evaluation of different structural designs demonstrates that incorporating a core-shell nanofiber structure achieves a favorable balance of pressure resistance, tissue adhesion, and seal retention under wet conditions. Acute leak closure was evaluated in five animals, and long-term safety was assessed in three animals followed for 1 month. The mean air leak volume decreased from 46.2 to 1.8 mL/min, with post-treatment air leak volumes below the clinically accepted threshold (≤ 10 mL/min) in all five animals. No treatment-related complications were observed during the follow-up period. Thus, electrospun nanofiber sheets represent a promising and biosafe approach for pulmonary air leak closure.
PMID:
42845019
Bibliographic data and abstract were imported from PubMed on 08 Oct 2026.
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