Photoinduced metal-free cascade silylation/cyclization of alkynes/alkynones with hydrosilanes to access 3-silylated benzothiophenes and thioflavones.

Authors

Yunfei Tian, Weijun Fu, Zhiqiang Wang, Xi Li, Jinzhao Ren, Yukai Liu, Luping Zheng, Kai Sun, Zejiang Li

Published in

Organic & biomolecular chemistry. Oct 08, 2026. Epub Oct 08, 2026.

Abstract

A metal-free photocatalytic method for the synthesis of silylated thioflavones and benzothiophenes has been established through cascade silylation/cyclization of alkynes/alkynones with hydrosilanes. This transformation features mild reaction conditions, excellent functional group compatibility, and broad substrate scope. Moreover, this method can be readily applied to the late-stage silylation of structurally complex bioactive molecules, thus offering potential applications for pharmaceutical research. Mechanistic investigations indicate that this reaction proceeds through a radical pathway.

PMID:
42845009
Bibliographic data and abstract were imported from PubMed on 08 Oct 2026.

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