Vascularized Brain Organoid: A Versatile Platform Models Brain Cancer and Traumatic Brain Injury.

Authors

Shu-Wei Angela Huang, Chin-Hsing Annie Lin

Published in

bioRxiv : the preprint server for biology. Aug 12, 2026. Epub Aug 12, 2026.

Abstract

Human iPSC-derived brain organoids are revolutionizing tools to study layers biology, synergize disease modeling, and accelerate therapeutic discoveries that overcome obstacles in monolayer cell culture or animal models. The neurovascular unit including vasculature and microglia is critical for brain development, maintenance of synaptic plasticity and neural activity, and the high metabolic demands of long-term culture. We present a methodology to incorporate these important components during organoid generation and discuss potential approach, aiming consistent production of vascularized organoids for longitudinal study. We also demonstrate that this vascularized organoid is a versatile platform to model brain cancer and traumatic brain injury.

PMID:
42845529
Bibliographic data and abstract were imported from PubMed on 08 Oct 2026.

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