Authors
Flavio Masato Kawamoto, Roberto De-Cleva, Denis Pajecki, Daniel Riccioppo Cerqueira Ferreira Oliveira, Leila Antonangelo, Priscila Caproni, Marco Aurelio Santo
Published in
Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery. Volume 39. Pages e1980. Epub Oct 05, 2026.
Abstract
Roux-en-Y gastric bypass promotes weight loss in patients with severe obesity and improves type 2 diabetes mellitus, which, in some cases, can lead to remission. The action of enteric hormones is relevant for the initial outcomes and late disease evolution.
To evaluate the influence of enteric hormone secretion on the evolution of type 2 diabetes mellitus three years after Roux-en-Y gastric bypass.
A total of 20 patients were evaluated, divided into 2 groups: group 1, glycated hemoglobin<6%, and group 2, glycated hemoglobin≥6%. Hormone secretion (ghrelin, GLP-1, and GIP) was analyzed at pre-specified time points following a standard meal.
Group 1 had higher mean secretion at 30 and 120 minutes ([992.60±806.78 vs. 407.97±186.80, p=0.039, p<0.05] and [418.72±219.11 vs. 240.14±121.11, p=0.037, p<0.05], respectively) than group 2. Group 1 presented higher GLP values at 60 [724 (195-1,483) vs. 214 (67-424), p=0.038, p<0.05], 90 [473 (200-943) vs. 180 (120-318), p=0.016, p<0.05] and 120 minutes [565 (278-770) vs. 163 (81-339), p=0.008, p<0.05] compared to group 2. There was no difference between the groups regarding ghrelin.
Higher secretion of GIP and GLP-1 was observed in patients with type 2 diabetes mellitus remission. The incretin factor is important in late disease evolution even in a group of patients with severe diabetes.
PMID:
42848683
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.
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