Running on ROS: redefining metabolic adaptation and healthy aging.

Authors

Jaydeep Sharma, Mahima Kumari, Sam J Mathew

Published in

Trends in endocrinology and metabolism: TEM. Oct 08, 2026. Epub Oct 08, 2026.

Abstract

Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of antioxidant signaling. Xirouchaki et al. show that NRF2 activation in skeletal muscle regulates metabolic homeostasis and healthy aging. Complementary evolutionary adaptations enhancing NRF2 signaling in horses underscore its role in muscle function and metabolism.

PMID:
42850097
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

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