Antibiotic-loaded microparticles for topical treatment of wounds: A scoping review.

Authors

Maria Cecília Negreiros Ciffoni, Giovanna Araujo de Moraes Trindade, Marcel Henrique Marcondes Sari, Roberto Pontarolo, Raul Edison Luna Lazo, Luana Mota Ferreira

Published in

Journal of pharmaceutical sciences. Pages 104538. Oct 08, 2026. Epub Oct 08, 2026.

Abstract

This scoping review aimed to map the evidence on antibiotic-loaded microparticles developed as controlled-release systems for topical wound treatment. The review followed the JBI methodology and was reported in accordance with the PRISMA-ScR checklist. The most frequently investigated antibiotics were gentamicin (n = 4; 21.1%), ciprofloxacin (n = 3; 15.8%), and doxycycline (n = 3; 15.8%), followed by vancomycin, mupirocin, and rifamycin (n = 2; 10.5% each). Chitosan and gelatin were the most common matrices (n = 6; 31.6 % each), followed by alginate (n = 3; 15.8%). Most systems were incorporated into wound dressings, scaffolds, hydrogels, patches, or used as powder. Excisional wounds were the most frequently evaluated model (n = 12; 63.2%), followed by infected wounds (n = 5; 26.3%), whereas burn and diabetic wound models were less investigated (n=1, 5.3%). These findings suggest that antibiotic-loaded microparticles may act as multifunctional wound-care systems by combining infection control, controlled local antibiotic release, and support for wound healing.

PMID:
42849875
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

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