Contraceptive use and GLP-1 receptor agonists: an intersection of metabolic and reproductive health.

Authors

Halina M Yee, Leo L Han

Published in

American journal of obstetrics and gynecology. Oct 08, 2026. Epub Oct 08, 2026.

Abstract

The growing overlap of glucagon-like peptide-1 receptor agonists and contraceptive use in women of reproductive age warrants a comprehensive understanding of the pharmacokinetic and pharmacodynamic interactions of these two drug classes. Studies that evaluate the two are limited, and significant knowledge gaps remain regarding interactions. This narrative review synthesizes the current body of literature surrounding glucagon-like peptide receptor agonists and hormonal contraception and their effects on the female reproductive tract. It defines potential interactions between the two classes of medication across the female reproductive tract, and highlights gaps in knowledge. Lastly, this review underscores the need for healthcare providers to incorporate contraceptive counseling as a routine component of care when initiating glucagon-like peptide 1 agonists.

PMID:
42849807
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

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