Value of Dual-Time-Point [¹⁸F]Fluorocholine PET/CT for Challenging Preoperative Parathyroid Imaging.

Authors

Adrien Latgé, Léonor Chaltiel, Claire Renaud, Laurent Guillon, Solange Grunenwald, Beatrice Herbault Barres, Séverine Brillouet, Mathieu Sinigaglia, Lavinia Vija Racaru

Published in

Journal of nuclear medicine : official publication, Society of Nuclear Medicine. Oct 08, 2026. Epub Oct 08, 2026.

Abstract

[¹⁸F]fluorocholine ([¹⁸F]FCH) PET/CT localizes hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism, but the optimal imaging time remains uncertain. We evaluated the added value of a 60-min acquisition after a 10-min acquisition. Methods: Patients with primary hyperparathyroidism who underwent parathyroid surgery after [¹⁸F]FCH PET/CT were included in the study. PET/CT was performed 10 min (early) and 60 min (delayed) after [¹⁸F]FCH injection. Gland location, SUV_max, SUV_peak, and parathyroid-to-thyroid ratio were reported. Results: Among 162 glands surgically removed in 119 patients, the median SUV_max (5.5 vs. 4.9, P < 0.01) and parathyroid-to-thyroid ratio (1.6 vs. 1.4; P < 0.01) were higher at 60 min versus 10 min, whereas the SUV_peak did not significantly differ between acquisition times. Delayed [¹⁸F]FCH PET/CT produced visually superior images for 36 of 113 resected PET-positive glands and changed the clinical interpretation for 23 (19.3%) of 119 cases, revealing an adenoma after a negative early scan in 8 patients. Conclusion: Although early imaging can provide more information, selective delayed imaging offers improved contrast and confidence in negative or equivocal cases.

PMID:
42850041
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.