MIND diet-related plasma proteins are associated with Alzheimer's disease risk.

Authors

Shane Fernandez, Desarae A Dempsey, Soumilee Chaudhuri, Yen-Ning Huang, Tamina Park, Shiwei Liu, Frederick W Unverzagt, Sujuan Gao, Global Neurodegeneration Proteomics Consortium, Donna M Wilcock, Jiaqi Yang, Casey M Rebholz, Shannon L Risacher, Andrew J Saykin, Kwangsik Nho

Published in

Alzheimer's & dementia : the journal of the Alzheimer's Association. Volume 22. Issue 10. Pages e71884.

Abstract

Adherence to the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet is associated with reduced dementia risk, but underlying mechanisms remain unclear.
Plasma proteomics (SomaScan 7k) from 206 Indiana Alzheimer's Disease Research Center participants were analyzed using network analysis to identify modules associated with MIND diet scores. Diet-related hub proteins were then investigated for associations with Alzheimer's disease (AD) phenotypes and as potential diet-AD outcome mediators. Validation analyses were conducted in the Atherosclerosis Risk in Communities study (n = 10,228) and Global Neurodegeneration Proteomics Consortium (n = 3,723) datasets.
Higher MIND diet scores were associated with lower AD odds (odds ratio = 0.75, p = 0.01) and lower plasma neurofilament light chain levels (β = -0.07, p = 0.02). Two proteins, MCTS1 and cytidylate kinase, were associated with MIND diet and AD risk, and may mediate their relationship (p[a × b < 0] ≥ 0.95). Validation analyses supported the MCTS1 finding.
Vascular-related biological mechanisms may underlie associations between diet and dementia risk.

PMID:
42851206
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

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