Authors
Yaru Guo, Shihan Zhang, QinQin Li, Yixuan Lu, Yachao Xu, Xiaohua Guo, Fangyong Liu, Youxing Liu, Shaojun Guo, Xuliang Deng
Published in
Advanced materials (Deerfield Beach, Fla.). Pages e75228. Oct 09, 2026. Epub Oct 09, 2026.
Abstract
Photocatalytic two-electron oxygen reduction reaction (ORR) toward H2O2 synthesis is a compelling approach for clinical antibacterial applications. Yet its selectivity is hampered by the competing four-electron ORR, which compromises both H2O2 generation kinetics and antibacterial efficiency. Herein, we report a new nanoscale confinement strategy for the controllable synthesis of covalent organic frameworks (COFs) confining isolated platinum nanoclusters (NCs) to enhance Pauling-type of O2 adsorption to achieve two-electron oxygen reduction for efficient antibacterial therapy. The resulting Tfp-Db COFs@Pt NCs exhibits a significantly higher H2O2 formation kinetics (3.12 × 10-3 mol L-1 h-1) than Tfp-Db COFs@Pt nanoparticles (1.55 × 10-3 mol L-1 h-1), with 2e- ORR selectivity increased from 45.0% to 86.0%. Experimental and theoretical results reveal a two-step single electron oxygen reduction pathway for H2O2 photosynthesis over Tfp-Db COFs@Pt NCs. The Tfp-Db COFs@Pt NCs exhibits excellent sterilization efficiencies of 5.0 log10CFU mL-1 and 5.2 log10CFU mL-1 against S. aureus and E. coli, respectively, exceeding most reported materials. Furthermore, Tfp-Db COFs@Pt NCs facilitate the regeneration of infectious wounds, with the efficiency of nearly 100% on day 10, outperforming previously reported bionanomaterials. Collectively, this work presents a new strategy for regulating the Pauling-type of O2 adsorption to enhance the photocatalytic H2O2 formation for wound healing application.
PMID:
42851146
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 5
- Comments 0