Durable Vessel Patency Achieved by Drug-Coated Balloon-Only Percutaneous Coronary Intervention in Triglyceride Deposit Cardiomyovasculopathy.

Authors

Kyoka Uchiumi, Yasuhiro Nakano, Shunsuke Katsuki, Keiji Oi, Tetsuya Matoba, Kohtaro Abe

Published in

JACC. Case reports. Pages 110636. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Triglyceride deposit cardiomyovasculopathy (TGCV) causes triglyceride accumulation in cardiomyocytes and vascular smooth muscle cells, leading to diffuse coronary artery disease and frequent restenosis after percutaneous coronary intervention.
A 37-year-old man with diabetes mellitus presented with diffuse 3-vessel coronary disease. Angiography and computed tomography revealed concentric diffuse coronary stenoses, and intravascular ultrasound demonstrated periadventitial low-echoic structures. Iodine-123-β-methyl-iodophenyl pentadecanoic acid scintigraphy showed a severely reduced washout rate, supporting the diagnosis of TGCV. The patient underwent percutaneous coronary intervention using a cutting balloon followed by drug-coated balloon angioplasty without stent implantation. No restenosis was observed by angiography at 1 year or computed tomography at 3 years.
This case suggests that a stentless revascularization strategy using a drug-coated balloon may be a feasible option in TGCV, potentially avoiding pathological vascular responses associated with permanent metallic scaffolds.
Stentless intervention may represent a promising therapeutic option in patients with TGCV.

PMID:
42853169
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

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