Authors
Kanokwan Nahok, Chalongchai Chalermwat, Ubon Cha'on, Apinya Jusakul, Patcharee Boonsiri, Angkor Chamdam, Ratthaphol Kraiklang, Patcharaporn Tippayawat, Sirirat Anutrakulchai, Worachart Lert-Itthiporn
Published in
Future science OA. Volume 12. Issue 1. Pages 2738750. Epub Oct 09, 2026.
Abstract
Patients with chronic kidney disease (CKD) may be vulnerable to thiamine insufficiency due to dietary restrictions, altered metabolism, and renal replacement therapy. We aimed to determine the prevalence of functional thiamine deficiency, its distribution across CKD stages, and the associated clinical factors in a Thai population.
Thiamine status was assessed in red blood cells using the erythrocyte transketolase activity coefficient (ETKAC) assay. Participants (n = 605) were categorized as having normal thiamine status (ETKAC ≤1.25) or functional thiamine deficiency (ETKAC >1.25). The prevalence of functional thiamine deficiency was 6.1% overall and 6.4% among participants with CKD. Univariate analyses of participants with CKD showed that higher systolic blood pressure (SBP), hypertension, and lower estimated glomerular filtration rate (eGFR) were associated with functional thiamine deficiency. In the multivariable analysis adjusted for age, sex, SBP, eGFR, and alcohol intake, hypertension remained independently associated with functional thiamine deficiency (β = 2.202; 95% confidence interval (CI) for the corresponding odds ratio (OR): 2.311-35.383; p = 0.002).
Functional thiamine deficiency was observed in a subset of participants, particularly in patients with CKD and hypertension, supporting further investigation of thiamine status in CKD populations.
PMID:
42852733
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.
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