Fertility counseling and preservation considerations in patients with gynecologic and non-gynecologic BRCA and Lynch-associated malignancies.

Authors

Anna Weimer, Nadeem Abu-Rustum, David Mutch, Mauricio Cuello, Angélica Fletcher, Hextan Y S Ngan, Nozomu Yanaihara, Rene Pareja, Christina Fotopoulou, Kenneth Ruzindana, Ka Yu Tse, Yana Zou, Neerja Bhatla, Ting-Chang Chang, Munanchiso Ndukwe Iheme, Jalid Sehouli, Nicole Conchin, Eva Chalas, Sarikapan Wilailak, Barbara Schmalfeldt, Alexander B Olawaiye

Published in

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Lynch syndrome and BRCA-mutation associated malignancies are fortunately rare. Affected patients have an increased risk of cancer diagnosis at a young age, often significantly overlapping with their reproductive years. In helping these patients, oncologists must navigate the following areas of care: cancer prevention, impact of cancer prevention strategies on fertility, impact of cancer treatment on fertility, effective cancer therapies, and preservation of fertility without compromising oncologic outcomes. This intersectionality between fertility preservation and effective cancer prevention/therapy makes the care of these patients extremely complex. With the utility of multidisciplinary care models, careful employment of evolving new treatment strategies, it is possible for patients to achieve their fertility desires while at the same time being protected from the risks imposed by their genetic mutations.

PMID:
42852624
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.