Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance.

Authors

Signe Bedsted Clemmensen, Nanna Mørk, Julie A Jensen, Lisbeth Aagaard Larsen, Bettina Bundgaard, Marianne Nygaard, Michelle Møhlenberg, Morten K Skouboe, Adrian Gervais, Paul Bastard, Anne Puel, Aurelie Cobat, Jean-Laurent Casanova, Kaare Christensen, Trine H Mogensen

Published in

Journal of human immunity. Volume 2. Issue 6. Nov 02, 2026. Epub Oct 09, 2026.

Abstract

Autoantibodies (auto-Abs) neutralizing type I interferons (IFN-I) underlie various life-threatening viral infections, and the prevalence of these auto-Abs rises sharply between 65 and 70 years of age. We investigated the familial aggregation of neutralizing IFN-I auto-Abs by assessing concordance rates in Danish older twins, including 3,270 twins aged 65-96 years in a sample comprising 1,318 intact twin pairs (2,636 individuals) and 634 twins from broken twin pairs (634 individuals). Neutralizing IFN-I auto-Abs were detected in 1.5% (50/3,270) of all twins tested, including 1.4% (37/2,636) in twins from intact pairs and 2.1% (13/634) in twins from broken pairs. A total of 50 twins had neutralizing IFN-I auto-Abs, including one concordant monozygotic pair and 35 discordant pairs, yielding a low overall concordance rate. A slight, but nonsignificant, increase in mortality was associated with harboring neutralizing IFN-I auto-Abs. Collectively, these findings do not reveal any familial aggregation of IFN-I auto-Abs, arguing against a strong germline genetic etiology of IFN-I auto-Abs in older adults.

PMID:
42853147
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.