Authors
Catarina Ferreira, Vítor Henrique Duarte, Nicky Akbarian, Antonio Bognanni, Sara Gil-Mata, Ana Margarida Pereira, Manuel Marques-Cruz, Torsten Zuberbier, Holger J Schünemann, João A Fonseca, Jean Bousquet, Rafael José Vieira, Bernardo Sousa-Pinto
Published in
Allergologie select. Volume 10. Pages 296-302. Epub Sep 25, 2026.
Abstract
Allergic rhinitis (AR) impairs quality of life. While most trials assess regular regimen medication use, mobile-Health (mHealth) data suggest that most patients use treatments on an as-needed basis.
Protocol for a systematic review comparing as-needed versus regular AR treatment regimens regarding efficacy and safety.
We will conduct a systematic review and network meta-analysis (NMA) of randomized controlled trials involving patients of any age with perennial or seasonal AR. Oral and intranasal drugs will be compared in an as-needed regimen versus a regular regimen or placebo. Primary outcomes will be the Total Nasal Symptom Score, the Total Ocular Symptom Score, and the Rhinoconjunctivitis Quality-of-Life Questionnaire.
This review will evaluate the efficacy and safety of two different strategies for AR management. The findings of this review will inform the Allergic Rhinitis and its Impact on Asthma (ARIA) 2024-2025 guidelines.
PMID:
42852172
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.
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