Recent advances in the intramolecular cyclizations of nitrones.

Authors

Qing-Mei Li, Zi-Han Hu, Zhang-Wei Liu, Hong-Yan Bi, Xin-Xian Zhong, Dong-Liang Mo

Published in

Organic & biomolecular chemistry. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Nitrones are versatile building blocks and their intramolecular cyclizations have served as powerful strategies to construct useful and important N-heterocycles. This review summarizes recent advances in the intramolecular cyclizations of nitrones for the preparation of distinctive N- or N,O-heterocycles over the past fifteen years. Herein, we focus on various cyclizations of N-alkyl, N-aryl, N-alkenyl, and N-allenyl nitrones, including direct cyclization, O-transfer reaction, electrocyclization, skeletal rearrangement, intramolecular cycloaddition, and related cascade reactions, and their applications in the total synthesis of natural products and alkaloids through intramolecular cyclization of nitrones.

PMID:
42853215
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

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