Beyond WEIRD populations: Interpreting the gap between subjective cognitive complaints and objective impairment.

Authors

Isabel Manica, Marcelo D Mendonça

Published in

Journal of Alzheimer's disease : JAD. Pages 13872877261497234. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Subjective cognitive complaints (SCC) are shifting from a quasi-diagnostic marker to a multidimensional clinical signal. Leniz et al. use the semi-rural Chilean MAUCO cohort to extend this debate beyond Western-dominated settings. They show a subjective-objective discrepancy: baseline objective performance did not predict incident SCC, whereas benzodiazepine use, and depressive symptoms did, highlighting affective and iatrogenic influences. Yet SCC predicted incident cognitive impairment. We argue that these findings are better interpreted by a model of SCC with at least two-components: affective/iatrogenic and degeneration-related components. In resource-limited contexts, SCC may aid risk-enrichment while prompting medication and mood review.

PMID:
42852840
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

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