Substituent-dependent stereochemical behavior in chloride-induced ring-cleaving substitution of chiral 3,3-dialkylcyclobutanones at an all-carbon quaternary center.

Authors

Shunsuke Matsui, Kazuki Usuguchi, Shohei Hamada, Shuichi Fukuyoshi, Tomoyuki Yoshimura, Jun-Ichi Matsuo

Published in

Chemical communications (Cambridge, England). Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Stereochemical outcomes of chloride-induced ring-cleaving substitution at the quaternary carbon of chiral 3,3-dialkylcyclobutanones were examined. The transformation affords 3-chloro ketones with predominant inversion of the configuration.

PMID:
42853029
Bibliographic data and abstract were imported from PubMed on 09 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.