Authors
Kuangxin Chen, Ji Chen, Miao Ding, Yi Rong, Yuanqi Guo, Yongming Li, Binbin Tao, Yanlong Song, Xingxing Wu, Lei Chen, Rui Li, Mouyan Jiang, Zhaoxian Li, Shaoting Jia, Yunya Wu, Yulai Wei, Yinjun Jiang, Hairong Liu, Shuhui Ji, Wenge Ma, Xishuang Shan, Wenrong Zhong, Wen Xu, Xianyao Liao, Lu Chen, Xiya Zhang, Junzhi Luo, Xuefan Cui, Hongrui Luo, Fei Liu, Houpeng Wang, Zhixian Qiao, Xiaocui Chai, Fang Zhou, Daji Luo, Shunping He, Zuoyan Zhu, Vance L Trudeau, Chutian Ge, Wei Hu
Published in
Science advances. Volume 12. Issue 41. Pages eaeg3698. Oct 09, 2026. Epub Oct 09, 2026.
Abstract
Fish show exceptional diversity in sex-determination mechanisms, making them a powerful system for studying how these pathways evolve. However, no definitive master sex-determining gene has yet been identified in Cyprinidae, a widely distributed and species-rich fish family. Here, we identified a male-specific gene in common carp encoding Pangu, a helix-loop-helix (HLH) domain peptide localized to Sertoli cells. Loss- and gain-of-function analyses demonstrate that pangu is both necessary and sufficient for male sex determination. Expression and reporter assays indicate that pangu represses cyp19a1a, a key regulator of ovarian differentiation, and disruption of cyp19a1a restores testicular development in the feminized phenotype of XY pangu mutants. These findings establish pangu as the master sex-determining gene in common carp and link an HLH domain peptide to sex differentiation.
PMID:
42853950
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.
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