Dishevelled-mediated clustering stabilizes Frizzled6 and Vangl2 to establish planar cell polarity in the mammalian skin.

Authors

Parijat Sil, Brandon Trejo, Katherine A Little, Danelle Devenport

Published in

Science advances. Volume 12. Issue 41. Pages eaeh6920. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Planar cell polarity (PCP) in epithelia is characterized by the polarized distribution of two opposing, membrane-associated PCP complexes across cell junctions. Transmembrane components of the PCP complex bridge cell junctions and organize into punctate, intercellular assemblies that exhibit a high degree of stability. Here, we define the contributions of the cytoplasmic PCP protein, Dishevelled (Dvl), in the submicrometer scale organization and stability of PCP complexes. Using endogenously tagged fluorescent PCP reporters in the embryonic mouse epidermis, we quantify PCP protein mobility and clustering during polarization. We find that as transmembrane proteins immobilize into puncta, Dvl2/3 coaccumulates with its transmembrane partner Frizzled 6 in a polarized manner and stabilizes clusters of PCP complexes. We identify a previously unknown function for the oligomerizing Dishevelled/Axin (DIX) domain of Dvl3, typically associated with Wnt signaling, in Dvl3 asymmetric localization. These observations underscore a role for Dvl oligomerization in assembly and stabilization of asymmetric PCP puncta.

PMID:
42853918
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

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