Mortality involving non-rheumatic valvular heart disease and atrial fibrillation in the United States: Long-term trends and implications.

Authors

Ibtissam ElGhazzani, Youssef Ramadan, Alyaa Ahmed Ibrahim, Maryam Saghir, Muhammad Sarim Azad Khan, Karim Othman Abdelnaim, Moustafa Ahmed Elsayed, Abdul Samad, Amr Arafa, Krish Patel, Eshal Saghir, F N U Sahil, Maha Sajjad, Yahya Samadi, Mohamed Fawzi Hemida

Published in

Medicine. Volume 105. Issue 41. Pages e51020. Oct 09, 2026.

Abstract

Non-Rheumatic valvular heart disease (NRVHD) and atrial fibrillation (AF) are major contributors to cardiovascular mortality in the U.S. Their coexistence increases the risk of stroke, heart failure, and death.This study examines national trends in deaths involving both NRVHD and AF in the United States from 1999 to 2023. Centers for disease control and prevention - Wide-Ranging Online Data for Epidemiologic Research data (1999-2023) were analyzed for adults with AF (I48) and NRVHD (I34-I36) as contributing causes of death. Age-adjusted mortality rates (AAMRs) were calculated per 100,000 population. Joinpoint regression analysis was used to determine average and annual percent change (AAPC) and annual percent change. From 1999 to 2023, a total of 141,846 deaths in the U.S. involved both AF and NRVHD. The AAMR increased from 2.98 in 1999 to 7.30 in 2023 (AAPC: 4.17; P < .001). Males had higher overall AAMR (5.31) (AAPC: 4.73) than females (4.02) (AAPC: 3.58). Non-hispanic Whites had the highest overall AAMR (5.17) while Hispanics had an AAMR of (1.88). Regionally, West had the highest overall AAMR (5.73), followed by the Northeast (4.81), the Midwest (4.79), and then the South (3.48). Majority of the deaths occurred in inpatient medical facilities (49,170 deaths, 35.0%). The age group 65 + showed the highest mortality (crude mortality rate: 11.93). Rural areas had higher overall AAMR (4.36) compared to urban areas (4.10). Deaths involving both AF and NRVHD increased from 1999 to 2023, with greater burden among older adults, males, rural areas, the West region, and non-Hispanic White population.

PMID:
42854009
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

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