Advancements in Technologies Targeting Horizontal Gene TransferRoutes to Control Drug Resistance Evolution.

Authors

Samuel Chetachukwu Adegoke, Md Adnan Karim, Maurelio Cabo Jr, Ignatius Senyo Yao Yawlui, Dennis LaJeunesse

Published in

ACS bio & med chem Au. Volume 6. Issue 3. Pages 210-236. Jun 17, 2026. Epub Apr 09, 2026.

Abstract

The global rise of multidrug-resistant (MDR) bacteria poses a major public health crisis, threatening the effectiveness of modern medicine. Traditional antibiotic development struggles to keep pace with bacterial evolution, largely due to the rapid dissemination of antibiotic resistance genes via horizontal gene transfer (HGT). HGT mechanisms both canonical and noncanonical enable bacteria to acquire resistance traits defining species and even special challenges. In this review, we cover the current understanding of HGT in spreading antibiotic resistance and explore possible strategies to control HGT and slow the spread of antimicrobial resistance. Recent advances highlight the potential of synthetic competence inhibitors, advanced oxidation processes (AOPs), CRISPR-Cas technologies, gene drives, and antiplasmids to disrupt horizontal gene flow and mitigate resistance evolution. Despite promising laboratory results, challenges remain in translating these approaches into clinical and environmental applications. Blocking HGT could complement antimicrobial stewardship programs and traditional antibiotic therapies by curbing the emergence of new resistant strains at their genetic roots. By targeting the foundational mechanisms of resistance acquisition, these strategies offer a proactive pathway to extend the efficacy of existing antibiotics and prevent a "postantibiotic" era. Ongoing research into bacterial pathogenesis, genome defense systems, and innovative gene-editing technologies will be critical to developing effective, scalable solutions for managing MDR infections worldwide.

PMID:
42325637
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

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