Authors
Malú Gámez Tansey, Sasha Bozeat, Peter Ackerman, Alireza Atri, Christopher J Barnum, Patrik Brundin, Carlos Abreu de Carvalho, Adam S Fleisher, Ana Graf, Elizabeth Head, Geoffrey A Kerchner, Hartmuth C Kolb, Akihiko Koyama, Mariel Kozberg, Cheryl E G Leyns, Jorge J Llibre-Guerra, Niklas Mattsson-Carlgren, David McKissock, Melissa E Murray, Liana S Rosenthal, Carrie Rubel, Suzanne E Schindler, Julie A Schneider, Adam J Schwarz, Kirsten M Scott, Tamara Seredenina, Duygu Tosun, Rebecca L Wallings, Hong Wang, Donna M Wilcock, Maria Carrillo, Simin Mahinrad, Christopher J Weber
Published in
Alzheimer's & dementia (New York, N. Y.). Volume 12. Issue 3. Pages e70287. Epub Sep 14, 2026.
Abstract
Alzheimer's disease (AD) is a biologically heterogeneous condition with vascular, proteinopathic, metabolic, and immune processes jointly shaping its clinical expression, trajectory of progression, and response to therapeutic intervention. Common AD co-pathologies such as cerebral amyloid angiopathy, Lewy body pathology, α-synuclein, and transactive response DNA-binding protein of 43 kDa (TDP-43)/limbic-predominant age-related TDP-43 encephalopathy are also increasingly connected with cognitive decline and therapeutic response. Significant advances in biomarkers, including seed amplification assays, proteomic signatures, and emerging positron emission tomography tracers bolster the field's understanding of a biological staging model and discovery of previously unrecognized co-pathologies. The Fall 2025 Alzheimer's Association Research Roundtable (AARR) brought together academic, clinical, and industry leaders to discuss and explore the current advances in the heterogeneity and co-pathologies of AD, and their implications for diagnosis, clinical trial design, and precision treatment strategies. This paper presents key takeaways from the Fall 2025 AARR meeting.
PMID:
42741654
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.
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