Metabolic enzymes moonlighting as protein kinases and phosphatases.

Authors

Min Li, Guijun Liu, Li Yuan, Zhimin Lu

Published in

Trends in biochemical sciences. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Protein phosphorylation is a central and reversible mechanism regulating virtually all cellular processes and is classically mediated by the canonical protein kinome and phosphatome. However, beyond their traditional roles as metabolic catalysts, a subset of metabolic enzymes also exhibits noncanonical 'moonlighting' activities as protein kinases or phosphatases, directly linking metabolic states to phosphorylation-dependent signaling. These unexpected functions of enzymes involved in glucose, fructose, lipid, nucleotide, and creatine metabolism influence a broad spectrum of cellular processes, including chromatin remodeling, transcription, cell cycle progression, metabolism, autophagy, cell survival and death, and immune responses. As a result, metabolic enzymes are increasingly recognized as key regulators that bridge cellular metabolism and signaling networks, with important implications for both normal physiology and disease.

PMID:
42855414
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.