What determines premalignant fate? A tale of stromal-epithelial crosstalk.

Authors

Karolina Chwialkowska

Published in

Trends in molecular medicine. Oct 10, 2026. Epub Oct 10, 2026.

Abstract

The stroma architects early cancer by building a precancerous niche that supports the expansion of nascent tumors. Disrupting the niche limits tumor growth, and the niche alone may be sufficient to confer tumor-like behavior on otherwise normal epithelial cells. Could mapping the stromal niche transform premalignant risk management?

PMID:
42855367
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

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