Ocular Changes in Human Spaceflight.

Authors

Rohan Gupta, Roshan Dongre, William Langston, Brooke Stephanian, Abraham Alsawaf, Nicholas Panzo, Hamza Memon, Joshua Ong, Evan E Afshin, JangKeun Kim, J Morgan Micheletti, Christopher E Mason, Peter Wostyn, Sara R Zwart, Scott M Smith, C Robert Gibson, Ethan Waisberg, Mouayad Masalkhi, Jay C Buckey, Thomas Mader, Afshin Beheshti, Andrew G Lee

Published in

Progress in retinal and eye research. Pages 101535. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Spaceflight presents unique challenges to ocular health, with astronauts experiencing a range of visual disturbances in the setting of microgravity, radiation exposure, and other environmental factors. This review synthesizes knowledge about how spaceflight affects ocular anatomy and function. We outline the diagnostic and therapeutic limitations in microgravity, including constraints on imaging modalities, intracranial pressure measurement, and drug delivery. In addition, we examine common spaceflight-associated ocular pathologies, including spaceflight-associated neuro-ocular syndrome, corneal epithelial disruption, possible radiation-associated lens changes, and retinal or choroidal alterations. Drawing from evidence across human missions, terrestrial analogs, and experimental models, this review emphasizes the critical importance of vision to astronaut safety and mission success. Future directions include long-term ocular health monitoring, advancement of in-flight diagnostic capabilities, and multidisciplinary strategies to safeguard astronaut vision.

PMID:
42855039
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

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