ClotPro viscoelastic testing in coagulation disorders in dogs: a retrospective analysis.

Authors

Pavlos G Doulidis, Carolina Frizzo-Ramos, Larissa J Prankch, Barbara Rütgen, Iwan A Burgener, Nicole Luckschander-Zeller

Published in

Journal of veterinary internal medicine. Volume 40. Issue 5. Sep 01, 2026.

Abstract

Viscoelastic testing provides whole-blood assessment of coagulation, but clinical data on the performance of the ClotPro in dogs with naturally occurring diseases are limited.
To evaluate pathway coherence of ClotPro variables with routine coagulation tests and to explore disease-associated viscoelastic phenotypes, fibrinolysis, and hypercoagulability.
Eighty-four client-owned dogs admitted to a university hospital.
Retrospective cohort study. ClotPro variables (clotting time, amplitude at 10 min, maximum clot firmness, maximum lysis across extrinsic pathway test [EX], intrinsic pathway test [IN], fibrinogen test channel, aprotinin test [AP] channels) were compared with prothrombin time (PT), activated partial thromboplastin time (aPTT), platelet count (PLT), and D-dimer using Spearman correlation with Benjamini-Hochberg adjustment. Group differences were assessed with Kruskal-Wallis and Dunn's post hoc. Hyperfibrinolysis (HF) was defined using paired EX-AP. A hypercoagulability index (HCI) and platelet/fibrin-adjusted residual firmness were derived.
PT correlated with clotting time in EX channel (ρ = 0.48, q = 0.002) and aPTT with clotting time in IN channel (ρ = 0.42, q = 0.007). PLT correlated with maximum clot firmness in EX channel (EX_MCF) (ρ = 0.50, q = 0.001). maximum clot firmness in FIB channel correlated with EX_MCF (ρ = 0.58, q < 0.001) and maximum clot firmness in IN channel (ρ = 0.47, q = 0.003). maximum lysis in EX channel (EX_ML) correlated inversely with EX_MCF (ρ = -0.35, q = 0.028). D-dimer correlated with EX_ML (ρ = 0.30, q = 0.049). Group-level distributions overlapped substantially. HF was infrequent among cases (33% in dogs with hepatopathy and 21% in dogs with hemorrhagic diarrhea). The HCI differed across diseases (P = .0002), whereas platelet/fibrin-adjusted residual firmness did not.
ClotPro variables demonstrated pathway-specific coherence with routine coagulation testing and consistent fibrinolysis patterns. Disease states did not define discrete viscoelastic phenotypes, supporting case-level interpretation.

PMID:
42855436
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.