Authors
Marleen D Hekker, Adam J Bindas, Freya Darling Eriksen, Larissa Della Vedova, David Giron-Villalobos, Pablo Gallardo Molina, Robert A Koetsier, Celia R Berkers, Bas E Dutilh, Rampal S Etienne, Suzanne E Geerlings, Justin J J van der Hooft, Marnix H Medema, Constance Schultsz, Michael F Seidl, Jerry M Wells, Alan J Wolfe, Janneke H H M van de Wijgert, Marjon G J de Vos
Published in
The Lancet. Microbe. Pages 101535. Oct 09, 2026. Epub Oct 09, 2026.
Abstract
Urinary tract infections (UTIs), particularly cystitis, are among the most common bacterial infections worldwide, with a disproportionate burden on adult female individuals, who often have recurrence. The discovery of the urobiome, a low microbial biomass community in the urinary tract, has transformed our understanding of UTI pathogenesis and infection susceptibility. Experimental and omics approaches provide insights into the taxonomic and functional complexity of the urobiome, highlighting the importance of microbial metabolites, ecological interactions, and host-microbe dynamics. Polymicrobial interactions within the urobiome further modulate pathogenicity, with some microbes inhibiting or promoting uropathobionts. Advancing UTI management will require combining omics and experimental research with ecological and evolutionary insights. This approach can enable the development of personalised, non-antibiotic interventions, such as live biotherapeutics and prebiotics, to improve diagnostics, reduce antibiotic resistance, and enhance treatment efficacy.
PMID:
42854704
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.
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