ASTRUM-006 and the changing landscape of perioperative therapy for gastric cancer.

Authors

Hyung-Don Kim, Ian Chau, Raghav Sundar

Published in

Med (New York, N.Y.). Volume 7. Issue 10. Pages 101302. Oct 09, 2026.

Abstract

ASTRUM-006 provides phase 3 evidence that perioperative immune checkpoint inhibition improves event-free survival with Asian SOX-based chemotherapy in PD-L1-positive gastric cancer. Its postoperative chemotherapy-sparing strategy is attractive, although unmasking, event adjudication, and non-R0 or occult metastatic disease warrant consideration. The study nevertheless broadens the perioperative treatment framework and provides an important platform for refining patient selection and postoperative treatment intensity.

PMID:
42854679
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

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