Acceptability, Feasibility, and Preliminary Efficacy of a Digital Cognitive Intervention for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) in Older Adults.

Authors

Cutter A Lindbergh, Roger Altizer, James J Grady, Holly E Eddy, David C Steffens, Sarah Shizuko Morimoto

Published in

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. Sep 18, 2026. Epub Sep 18, 2026.

Abstract

We aimed to examine the acceptability, feasibility, and preliminary efficacy of a digital cognitive intervention (DCI) for older adults with post-acute sequelae of SARS-CoV-2 infection (PASC).
39 older adults (60-82 years old) with PASC neurocognitive symptoms (PASC-Neuro) were enrolled in a 6-week trial of neuroscience-based DCI. Treatment acceptability and feasibility were quantified via validated self-report questionnaires, recruitment and retention rates, and incidence of adverse events (AEs). Changes in clinical outcomes, collected before and after treatment, were examined using repeated measures statistical tests.
The DCI program was acceptable, credible, and usable to participants. Recruitment and retention rates were high (>85%). AEs were generally mild, transient, and tolerable. Significant improvements were observed in depression, anxiety, everyday functioning, and cognitive performance (set-shifting and verbal fluency).
These findings support the potential of a DCI program for older adults with PASC-Neuro.

PMID:
42855370
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

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