High-definition transcranial direct current stimulation (HD-tDCS) modulates neural response for face-emotion recognition in major depression.

Authors

Paloma Pfeiffer, Artemis Zavaliangos-Petropulu, Brandon Taraku, Jacquelyn Schneider, Viviane Norris, Suzanne D Kozikowski, Roger Woods, Michael Boucher, Mayank Jog, Katherine L Narr

Published in

Biological psychiatry. Cognitive neuroscience and neuroimaging. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Transcranial direct current stimulation (tDCS) may alleviate depressive symptoms. Using a face-emotion recognition fMRI task, we investigated whether left dorsolateral prefrontal cortex (DLPFC) high-definition (HD)-tDCS modulates neural circuitry associated with affective processing biases in major depressive disorder (MDD).
As part of an exploratory clinical trial, MDD patients were randomized to receive 12-daily 20-minute sessions of 2 mA active (n=37, age: 35.0±8.8years, 59%F) or sham (n=29, age: 33.0±10.5 years, 65%F) HD-tDCS. Clinical and task-fMRI data were collected pre- and post-treatment. Analyses compared blood-oxygen-level-dependent (BOLD) response over time between active and sham groups for processing of happy, fearful, and neutral face stimuli versus objects at the whole-brain level and within hippocampal and amygdala regions-of-interest (ROIs).
Whole-brain analysis showed significant group-by-time interactions for fearful faces versus objects in right fronto-parietal regions (FWE, p<0.05), with the active and sham groups exhibiting increased and decreased activation, respectively. Increased right-hippocampal BOLD response for happy or fearful faces, and all faces versus objects occurred for active HD-tDCS, but not for sham (FWE, p<0.05). Left-hippocampal activity decreased for happy faces versus objects in the sham group (p<0.05). Increased right-hippocampal activity for fearful versus objects correlated with improved anxiety in the active group (p<0.05).
Left DLPFC HD-tDCS modulated distributed cortical and hippocampal circuitry involved in emotional face processing. The association between right hippocampal activation and anxiety improvement suggests a potential role for hippocampal function in treatment response and warrants further investigation as a candidate neuroimaging biomarker.

PMID:
42855128
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

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