Authors
Yuanli You, Mingxing Yang, Xiuqing Wang, Wen Dong
Published in
Journal of medical case reports. Volume 20. Issue 1. Aug 31, 2026. Epub Aug 31, 2026.
Abstract
Primary mediastinal yolk sac tumor (PMYST) is an extremely rare and highly malignant germ cell tumor that predominantly affects young males and is associated with a poor prognosis.
We present the case of a 23-year-old non-smoking male diagnosed with stage III (cT4N0M0) PMYST who received comprehensive treatment guided by a multidisciplinary team (MDT). The treatment regimen included 5 cycles of neoadjuvant chemotherapy with BEP (bleomycin, etoposide, and cisplatin), followed by radical surgery, postoperative radiotherapy, and 4 cycles of adjuvant chemotherapy. Post-treatment, the patient's serum tumor markers normalized, with a partial radiological response (PR) and sustained biochemical remission. As of the latest follow-up in August 2025 (26 months after diagnosis), the patient remains in complete radiological and biochemical remission with no signs of recurrence.
This case demonstrates that an intensive MDT-guided multimodal approach incorporating aggressive neoadjuvant chemotherapy, radical surgery, and consolidative sequential radiotherapy and chemotherapy may lead to encouraging outcomes, including the achievement of complete radiological and biochemical remission documented at 26 months. However, this case is more reflective of individualized treatment for a specific patient, and it also highlights the need for intensified surveillance beyond two years.
PMID:
42855723
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.
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