Authors
M Sun, H Wu, Y Gao, S X Li, Z S Lu, H X Zhang, Z G Zhao, H B He, P Gao, Z M Zhu
Published in
Zhonghua yi xue za zhi. Volume 106. Issue 37. Pages 4041-4046. Oct 13, 2026.
Abstract
To investigate the efficacy in patients with primary aldosteronism (PA) who converted from adrenal ablation to surgical intervention or from surgical intervention to adrenal ablation. A retrospective analysis was performed on the clinical data of patients with PA who sequentially underwent transcatheter adrenal ablation and surgical intervention (regardless of treatment sequence) admitted to Daping Hospital, Army Medical University between June 2018 and June 2025. Patients were divided into the post-ablation surgery group and post-surgery ablation group according to the treatment sequence. Clinical data, PA classification, and primary causes for second intervention were collected. Biochemical and clinical outcomes after second treatment were evaluated in accordance with the PA surgical outcome criteria. A total of 10 patients were enrolled, including 8 males and 2 females, with the age of (42.6±14.0) years. There were 7 cases in the ablation-then-surgery group and 3 cases in the surgery-then-ablation group. Adrenal CT scans revealed nodular lesions (adenomas) in all 10 PA patients. The indications for the second intervention in both groups were persistent hypertension, failure to achieve the target plasma aldosterone-to-renin ratio, with or without hypokalemia, following the initial treatment. In the ablation-then-surgery group, 6 patients had left-sided lesions and 5 were male, with a median interval between the two procedures of 1.5 (1.0, 2.0) years. All patients in the surgery-then-ablation group were male, and the interval between the two procedures ranged from 2 to 12 years. Patients were followed-up 1 year after second intervention. The post-ablation surgery group exhibited complete biochemical success in 4 cases and partial biochemical success in 3 cases; complete clinical success was noted in 1 case and partial clinical success in 6 cases. In the post-surgery ablation group, complete biochemical success was seen in 3 cases, complete clinical success in 1 case, and partial clinical resolution in 2 cases. Male patients predominated among PA patients undergoing re-intervention, and favorable biochemical and clinical responses could be achieved by second intervention.
PMID:
42855774
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.
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